NIR-II Dye and NIR-I-II Dye

NEAR INFRA-RED dye TECHNOLOGY

Fluorescence-based optical imaging is indispensable to investigating biological systems with high spatial resolution and fast temporal speed.

Imaging in the second near infra-red window (NIR-II), beyond 1000nm, is promising for deep-tissue high resolution optical imaging in vivo:

Dye Nir-II Comparison.png
  • Compared to visible and near infra-red (below ~900nm), the NIR-II window enables reduced scattering of photons traversing through tissues
  • NIR-II optical window imaging can resolve in the sub-5 micron to sub-100 micron range at 3-5 millimeter depth though the intact body and brain of mice.
  • High speed/frame rate imaging allows for blood-flow speed mapping in individual capillary vessels, capable of resolving flow patterns within a single cardiac cycle of mice
  • Non-invasive brain imaging can be achieved without craniotomy
 NIR-II DYE: Vessel structure of mouse brain

NIR-II DYE: Vessel structure of mouse brain

Nirmidas’ NIR-II fluorophores are of high quantum yield and can be functionalized by a variety of targeting moieties for molecular imaging and vessel/organ imaging in vitro and in vivo.

NIR-II DYE Product

Nirmidas researchers have developed a near infra-red II (NIR-II) dye product (IR-E1050) with high quantum yield and high biocompatibility (renal excretion).

  • Large Stokes' shift
  • Excitation ( 785nm or 808nm); emission (900nm-1300nm)
  • High quantum yield
  • Low Toxicity
  • Rapid excretion from body
  • Functionalizable with a variety of targeting groups for molecular imaging and vessel/organ imaging in vitro and in vivo.
 

NIR-II dyes emission > 900 nm  

Research Use Only

Nirmidas NIR Dye is available to purchase today. Email us at sales@nirmidas.com or fill in the form below.

 

    NIR-I-II dyes emission > 800 nm, one photon/two photon

    NIR Dye Applications

    • Fluorescence imaging/spectroscopy in the NIR-1 window (800-1400nm)
    • Fluorescence imaging/spectroscopy in the NIR-II window (1000-1700nm)
    • Photoacoustic imaging
    • Flourescence molecular imaging
    • Small animal imaging
    • Intra-operative imaging
    • Contrast agents
    • Flourescence dye
    • Image guided procedures

    The first commercial NIR-II dye has been used for deep-tissue in vivo fluorescence imaging with various animal models related to:

    • cancer
    • brain
    • cardiovascular diseases
    • vascular imaging

    Research Use Only

    Nirmidas NIR Dye is available to purchase today. Email us at sales@nirmidas.com or fill in the form below.

     

    NIR-II Beads

    Research Use Only

    Nirmidas IRbeads are available to purchase today. Email us at sales@nirmidas.com or fill in the form below.


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    Publications

    "A Small-molecule dye for NIR-II imaging" Nature Materials, 15, 235-242, 2016.