NIR-II Dye and NIR-I-II Dye

NEAR INFRA-RED dye TECHNOLOGY

Fluorescence-based optical imaging is indispensable to investigating biological systems with high spatial resolution and fast temporal speed.

Imaging in the second near infra-red window (NIR-II), beyond 1000nm, is promising for deep-tissue high resolution optical imaging in vivo:

Dye Nir-II Comparison.png
  • Compared to visible and near infra-red (below ~900nm), the NIR-II window enables reduced scattering of photons traversing through tissues

  • NIR-II optical window imaging can resolve in the sub-5 micron to sub-100 micron range at 3-5 millimeter depth though the intact body and brain of mice.

  • High speed/frame rate imaging allows for blood-flow speed mapping in individual capillary vessels, capable of resolving flow patterns within a single cardiac cycle of mice

  • Non-invasive brain imaging can be achieved without craniotomy

 NIR-II DYE: Vessel structure of mouse brain

NIR-II DYE: Vessel structure of mouse brain

Nirmidas’ NIR-II fluorophores are of high quantum yield and can be functionalized by a variety of targeting moieties for molecular imaging and vessel/organ imaging in vitro and in vivo.

NIR-II DYE Product

Nirmidas researchers have developed a near infra-red II (NIR-II) dye product (IR-E1050) with high quantum yield and high biocompatibility (renal excretion).

  • Large Stokes' shift

  • Excitation ( 785nm or 808nm); emission (900nm-1300nm)

  • High quantum yield

  • Low Toxicity

  • Rapid excretion from body

  • Functionalizable with a variety of targeting groups for molecular imaging and vessel/organ imaging in vitro and in vivo.

 

NIR-II dyes emission > 900 nm  

Research Use Only

Nirmidas NIR Dye is available to purchase today. Email us at sales@nirmidas.com or fill in the form below.

View Limited Use License for Nirmidas Dyes

 

NIR-I-II dyes emission > 800 nm, one photon/two photon

NIR Dye Applications

  • Fluorescence imaging/spectroscopy in the NIR-1 window (800-1400nm)

  • Fluorescence imaging/spectroscopy in the NIR-II window (1000-1700nm)

  • Photoacoustic imaging

  • Flourescence molecular imaging

  • Small animal imaging

  • Intra-operative imaging

  • Contrast agents

  • Flourescence dye

  • Image guided procedures

The first commercial NIR-II dye has been used for deep-tissue in vivo fluorescence imaging with various animal models related to:

  • cancer

  • brain

  • cardiovascular diseases

  • vascular imaging

Research Use Only

Nirmidas NIR Dye is available to purchase today. Email us at sales@nirmidas.com or fill in the form below.


Learn more about Nirmidas NIR Dye

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Publications

"A Small-molecule dye for NIR-II imaging" Nature Materials, 15, 235-242, 2016.