Stanford scientists look deeper into the body with new fluorescent dye

Stanford News

Nirmidas Biotech Inc. has licensed a patent from Stanford University on biocompatible NIR-II dye that can be excited in the 600-900 nm range and fluoresces in the 900-1300 nm range. 

This NIR-II dye product (IR-E1100) has high quantum yield (~ 4 times higher than the Stanford dye and carbon nanotube based dyes), high biocompatibility, and can be renal excreted. This dye can be used for fluorescence imaging with low autofluorescence/low background ex vivo with cells and tissues. 

It is the first commercial NIR-II dye for deep-tissue in vivo fluorescence imaging with various animal models related to cancer, brain, and cardiovascular diseases and vascular imaging in general.  In vivo NIR-II fluorescence imaging can reach millimeters to centimeters tissue depth with spatial resolution in the sub-5 micron to sub-100 micron range. High temporal resolution can also be achieved to produce real-time imaging videos with imaging rate more than 30 frames per second. 

This dye holds a high potential for clinical translation for human use due to its large Stokes' shift (excitation 785nm or 808nm, emission 900nm-1300nm), high quantum yield, low toxicity and rapid elimination from body.