Plasmonic Gold Film Technology
Plasmonic gold allows for a significant improvement in signal-to-noise ratio, surpassing other substrates and beads by up to 100 fold in sensitivity and dynamic range. Plasmonic gold (pGOLD™) substrates and beads are useful for fluorescence and Raman based cellular imaging and molecular assays. Our pGold technology:
suppresses or blocks background signals
enables multi-color imaging
requires no additional assay steps
is compatable with standard cellular imaging, microarrays, and flow cytometric assay steps an equipment
pGOLD™, our innovative signal amplifying platform, originated from Stanford University and was published in Nature Communication and Nature Medicine. This technology is nano-engineered and uses a near-infrared enhanced fluorescence detection platform. The high sensitivity of the pGOLD™ technology has already be displayed in a novel diagnosis of Type 1 Diabetes; with pGOLD™, Type 1 Diabetes, while in its early stages, can be quickly and easily detected in hospitals around the world.
pGold Slides Product
Plasmonic gold (pGOLD™) substrates and beads reply on Nanoscience principles, such as nanogap enhanced excitation field strength and reduction in radiative lifetime of molecular excited states, to significantly increase the fluorescence emission of various fluorophores on the substrates.
The fluorescence enhancement is in the wavelength range of 500 – 900nm for Si based detectors and persists to > 1000 nm for infrared detectors. Substrates are compatible with fluorophores such as Cy3, Cy5, IRDye680, and IRDye800 dyes in this wavelength range and give the highest enhancement in the near-infrared window. The substrate can also enhance the Raman scattering signals of molecules by orders of magnitude.
Nirmidas pGold™ slides are available to purchase today. Email us at firstname.lastname@example.org or fill in the form below.
Research Use Only
Protein (Cytokine/antibody/antigen) detection
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"Validation of IgG, IgM multiplex plasmonic gold platform in French clinical cohorts for the serodiagnosis and follow-up of Toxoplasma gondii infection" Diagnostic Microbiology & Infectious Disease, 87, 213-218, 2017
"Diagnosis of Zika virus infection on a nanotechnology platform" Nature Medicine, advance online publication. 2017-03-06
"A plasmonic chip for biomarker discovery and diagnosis of type 1 diabetes” Nature Medicine, 20, 948-953, 2014.
"An Integrated Peptide-Antigen Microarray on Plasmonic Gold Films for Sensitive Human Antibody Profiling" PlosOne, Published online July, 2013.
"Multiplexed cytokine detection on plasmonic gold substrates with enhanced near-infrared fluorescence” Nano Research, 6 (2) 113-120 2013.
"Plasmonic substrates for multiplexed protein microarrays with femtomolar sensitivity and broad dynamic range" Nature Communications, 466, 1-9, 2011.
"Plasmonic Micro-Beads for Fluorescence Enhanced, Multiplexed Protein Detection with Flow Cytometry" Chem. Sci., 2014, DOI: 10.1039/C4SC01206B
Introduction to Plasmonic Technology (pGOLD™)
introduction to Plasmonic Technology
Broad florescence enhancement due to unique gold structure, applicable to various flat and curved surfaces
learn more about Nirmidas pgold slides
Applying pGOLD™ to Multiplexed Autoantibody Dectection vs. Nitrocellulose and glass, Ovarian Cancer Biomarker CA125 detection, and more.